STS-35 was the tenth flight of Space Shuttle Columbia, the 38th shuttle flight, and a mission devoted to astronomical observations with ASTRO-1, a Spacelab observatory consisting of four telescopes. The mission launched from Kennedy Space Center in Florida on 2 December 1990.
An in-depth write up about various versions of the STS-35 patch and variations can be found here.
White border version, twill background (not fully-embroidered). Taped tail suggests Cape Kennedy Medals.
There is also a matching 3" version.