The 45th Operations Group is a United States Air Force unit. It is assigned to the 45th Space Wing, stationed at Cape Canaveral Air Force Station, Florida.
The 45th Operations Group was responsible for program management and operation of five squadrons which perform all Eastern Range launch operations including Delta II, Delta III, Atlas II, Atlas III, Titan IV, Space Shuttle, Pegasus, and Athena space launch vehicles.
The Operations Group provides support to Naval Ordnance Test Unit operations. In support of space launch operations, the Operations Group coordinates training for the wing, manages all wing spacecraft services systems and facilities, and manages the Patrick AFB air traffic complex, handling more than 24,000 aircraft operations annually.